Short-term efficacy evaluation of single-session microwave ablation for benign thyroid nodules
10.16066/j.1672-7002.2024.07.002
- VernacularTitle:甲状腺良性结节单次微波消融治疗的短期疗效评价
- Author:
Junsong LIU
1
;
Chongwen XU
;
Xiaobao YAO
;
Ruimin ZHAO
;
Shiyang WANG
;
Qian ZHAO
;
Honghui LI
;
Yanxia BAI
;
Shaoqiang ZHANG
Author Information
1. 西安交通大学第一附属医院耳鼻咽喉头颈外科,陕西 西安 710061
- Keywords:
Thyroid Nodule;
Treatment Outcome;
microwave ablation;
solid volume;
volume reduction rate;
longitudinal diameter of nodule
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(7):414-420
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the short-term efficacy of single-session microwave ablation for benign thyroid nodule.METHODS Patients with benign thyroid nodules treated by microwave ablation between June 2019 and December 2022 at the Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,were included for analysis.Thyroid function was tested 1 month after treatment,and ultrasound and thyroid function were performed 3 months,6 months and 1 year after treatment.Volume reduction rates(VRR)of nodules were calculated.Data of the last follow-up within 1 year were included for analysis.Variables including gender,age,whether Hashimoto's thyroiditis was present,longitudinal diameter of nodules,solid volume of nodules were included for univariate and multivariate analysis.RESULTS A total of 151 patients with 163 nodules were included.The perioperative complication rate was 1.99%(3/151).The VRR at half year after treatment was(79.58±17.70)%,and the success rate at half year after treatment was 93.43%(128/137).The VRR of at 1year after treatment was(81.24±24.29)%.The 1-year treatment success rate was 92.77%(77/83).Univariate and multivariate analysis showed that nodular solid volume and age were independent factors affecting VRR after ablation.Regression coefficient of age and solid volume was 0.34(P<0.05)and-0.47(P<0.05),respectively.For every 1 cm3 increase in solid volume,1-year VRR(%)decreased by 0.47.Regression equation:1-year VRR=68.92+0.34×age-0.47×solid volume.Serum FT4 gradually decreased and the thyroid stimulating hormone(TSH)gradually increased within 6 months after ablation,and the differences were statistically significant(P<0.05).After 6 months,serum FT4 gradually recovered to the normal level and TSH gradually recovered.However,TSH still did not reach the preoperative level one year after ablation.FT3 decreased gradually after treatment,but there was no significant difference between the values at each time point(P=0.40).After the ablation of thyroid nodule,the mean value of thyroid function index fluctuated,but all of them were within the normal reference range.CONCLUSION Microwave ablation is a safe and effective treatment method for benign thyroid nodules,with an overall success rate of over 90%.Solid nodule volume and age are independent factors affecting the microwave ablation effect of benign thyroid nodules.
