Study on the clinical manifestations and objective inflammation indicators in patients with different nasal mucosal inflammation
10.16066/j.1672-7002.2024.06.007
- VernacularTitle:鼻黏膜不同炎症的临床表现及客观炎症指标的异同性研究
- Author:
Chengyao LIU
1
,
2
;
Xiangdong WANG
;
Symbat AGAT
;
Yutong SIMA
;
Zhongyan LIU
;
Luo ZHANG
Author Information
1. 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,耳鼻咽喉头颈外科学教育部重点实验室(首都医科大学),北京 100730
2. 北京市耳鼻咽喉科研究所,鼻病研究北京市重点实验室,北京 100005
- Keywords:
Rhinitis;
Sinusitis;
Nasal Polyps;
Nitric Oxide;
chronic rhinosinusitis without nasal polyps;
chronic rhinosinusitis with nasal polyps;
Sinonasal Outcome Test-22;
visual analogue scale
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(6):369-376
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To test whether there are some differences among chronic rhinitis,chronic rhinosinusitis patients with nasal polyps(CRSsNP)and without nasal polyps(CRSsNP)in symptom severity,health-related quality-of-life impairment,and objective inflammatory factors.METHODS A total of 154 consecutive patients who had been treated at the Otolaryngology Department of Beijing Tongren Hospital from January 2017 to December 2018 were recruited in this study.The patients aged 18-70 years,with 106 males and 48 females.All patients performed endoscopic examination,nasal exhaled nitric oxide(nNO),skin prick test(SPT),sinus CT scan,complete blood count,and fulfilled the visual analogue scale(VAS)self-assessment of nasal symptoms and the SNOT-22 questionnaire under the guidance of the physician.According to the inclusion criteria,A total of 43 patients with CR,58 patients with CRSsNP and 53 patients with CRSwNP were enrolled in our study.RESULTS The total SNOT-22 score in CRSsNP group was significantly lower than that in CR and CRSwNP groups(30.0±19.4 vs.41.1±21.9,30.0±19.4 vs.40.9±18.7,P<0.05),and there was no significant difference between CR group and CRSwNP group.The average scores of nasal symptoms and extranasal symptoms in CRSwNP group were the highest;the scores in CRSsNP group were lower.The impact of CR patients on sleep damage was significantly higher than that in CRSsNP patients(9.9±6.2 vs.5.1±5.3,P<0.05),and there was no significant difference between CR group and CRSwNP group(9.9±6.2 vs.7.1±5.7,P>0.05).When patients suffered with positive SPT,there was no statistical difference in symptom scores and SNOT-22 scores between CR,CRSsNP,and CRSwNP;but with negative SPT,there was a significant statistical difference in both symptom scores and SNOT-22 scores among the three groups.CONCLUSION CR,CRSsNP and CRSwNP have a significant impact on quality of life,respectively.In terms of symptom scores and quality of life scores,the CR group and CRSwNP group are similar and the scores are higher than that of the CRSsNP group.However,the objective inflammation factors are not consistent with the subjective symptom scores and quality of life scores.
