Clinical analysis of 38 patients diagnosed with head and neck extramedullary plasmacytoma
10.16066/j.1672-7002.2024.05.002
- VernacularTitle:38例头颈部髓外浆细胞瘤临床分析
- Author:
Lei YANG
1
;
Mingjie WANG
;
Lijie ZENG
;
Jianhua TAO
;
Chengji WANG
;
Liang WANG
Author Information
1. 首都医科大学附属北京同仁医院血液科,北京 100730
- Keywords:
Plasmacytoma;
Head and Neck Neoplasms;
Risk Factors;
Prognosis;
head and neck extramedullary plasmacytoma
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2024;31(5):278-282
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Investigating the clinical characteristics,risk factors,treatment strategies and prognosis of head and neck extramedullary plasmacytoma(HNEMP).METHODS To analyze indicators affecting survival and prognosis,retrospective study was conducted on the clinical data of 38 newly diagnosed and untreated patients with HNEMP who were admitted to Beijing Tongren Hospital from September 2008 to January 2022.RESULTS Among 38 patients,5 cases(13.2%)displayed a manifestation as cranial-nasal-orbital communication,and 8 cases(21.1%)involved a tumor with diameter≥5 cm.There were 17 patients(44.7%)who underwent surgical resection along,13 patients(34.2%)who received postoperative radiotherapy,8 cases(21.1%)who accepted chemotherapy,and 5 cases(13.2%)who experienced combined radiochemotherapy.Following treatment evaluation,32 cases achieved CR,3 cases showed PR,1 case demonstrated SD and 2 cases experienced PD.The median follow-up time was 86 months,with 5-year PFS and OS rates of 92.1%and 94.7%,respectively.Of note,the patients with cranial-nasal-orbital communication exhibited significantly unfavorable 5-year PFS and OS rates of 40%and 60%,respectively,with median PFS of 13 months,whereas the patients in other groups achieved 100%of 5-year PFS and OS rates.Additionally,tumor diameter≥5 cm and the involvement of cranial-nasal-orbital communication were adverse prognostic factors for both PFS and OS.CONCLUSION HNEMP is a rare disease and the primary treatment approach is surgery combined with radiotherapy.The prognosis for HNEMP tends to be relatively favorable,with the involvement of cranial-nasal-orbital communication and high tumor burden as the adverse prognostic indicators.
