Correlation between salivary cystatin D level and salivary gland injury in patients with primary Sj?gren syndrome
10.16016/j.2097-0927.202403115
- VernacularTitle:原发性干燥综合征患者唾液胱抑素D水平与唾液腺损伤的相关性分析
- Author:
Jing WANG
1
;
Fei LI
;
Yi HUANG
;
Lingfei MO
;
Hanchao LI
;
Ying PAN
;
Xiuyuan FENG
;
Xinyi LIU
;
Yuanyuan LI
Author Information
1. 710061 西安,西安交通大学第一附属医院风湿免疫科
- Keywords:
primary Sj?gren syndrome;
cystatin D;
salivary flow rate;
salivary gland ultrasonography
- From:
Journal of Army Medical University
2024;46(21):2451-2456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between salivary cystatin D level and salivary gland injury in patients with primary Sj?gren syndrome(pSS).Methods A total of 51 pSS patients admitted in the Department of Rheumatology and Immunology of the First Affiliated Hospital of Xi'an Jiaotong University from September 1,2022 to June 30,2023,and 51 age-and gender-matched healthy individuals who took physical examination in the hospital during same period were enrolled in the study.The level of salivary cystatin D was detected,and the difference in the level between the 2 groups was compared using an independent-samples t test.Pearson correlation analysis was applied to analyze the correlation between salivary cystatin D and clinical parameters in the patients.Results The pSS patients had significantly lower cystatin D level than the healthy controls(206.55±108.11 vs 374.32±172.24 pg/mL,P＜0.01).The cystatin D level in the pSS patients was positively correlated with both static(r=0.433,P=0.002)and dynamic salivary flow rates(r=0.363,P=0.009).The patients with higher score of salivary gland ultrasonography(SGUS)had obviously lower cystatin D than those with lower SGUS score(parotid gland:160.75±85.56 vs 290.53±95.17 pg/mL,P＜0.01;submandibular gland:157.76±87.59 vs 276.25±97.06 pg/mL,P＜0.01).The cystatin D level was also negatively correlated with peripheral blood IL-6 level(r=-0.453,P=0.001)and CD4+T cell count(r=-0.396,P=0.005)in the pSS patients.Conclusion Salivary cystatin D level can be used as an indicator of salivary gland damage for pSS patients.
