Mechanism of heterotopic ossification in ankylosing spondylitis:research progress
10.16781/j.CN31-2187/R.20240165
- VernacularTitle:强直性脊柱炎异位骨化发生机制的研究进展
- Author:
Yuening CHEN
1
;
Qing YU
;
Hongxiao LIU
Author Information
1. 中国中医科学院广安门医院风湿病科,北京 100053
- Keywords:
ankylosing spondylitis;
ectopic ossification;
ossification signaling pathway;
osteoblasts
- From:
Academic Journal of Naval Medical University
2024;45(12):1553-1560
- CountryChina
- Language:Chinese
-
Abstract:
Ankylosing spondylitis is a refractory autoimmune disease,and heterotopic ossification is one of the most important pathological features.The mechanism of heterotopic ossification in ankylosing spondylitis involves many aspects,including ossification-related genes,ossification-related factors,ossification-related cells,ossification signaling pathways,and mechanical stress.This article elaborates the pathogenesis of heterotopic ossification in ankylosing spondylitis from different aspects of multiple channels,pathways,targets,and factors,hoping to provide reference for expanding clinical and basic research and in-depth understanding of ankylosing spondylitis.
