Long-term donor safety analysis after related renal transplantation in a single center
10.16781/j.CN31-2187/R.20240161
- VernacularTitle:单中心亲属肾移植术后供者长期安全性分析
- Author:
Jiyuan WANG
1
;
Yu CHEN
;
Jinghui YANG
;
Xueyang ZHENG
;
Yue DING
;
Shu HAN
Author Information
1. 海军军医大学(第二军医大学)第二附属医院器官移植科,上海 200003
- Keywords:
living related renal transplantation;
kidney donors;
safety;
follow-up
- From:
Academic Journal of Naval Medical University
2024;45(11):1390-1394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the long-term safety of related kidney donors after unilateral nephrectomy.Methods A total of 91 related donors who received nephrectomy in our hospital from 2006 to 2011 were followed up for at least 10 years by outpatient,telephone,or WeChat.During the follow-up period,the serum creatinine,serum uric acid,blood urea nitrogen,estimated glomerular filtration rate(eGFR),hematuria,urinary protein,blood pressure,blood glucose and blood lipids of the donors were detected,and the changes before and after nephrectomy were analyzed.Results At 1 month after operation,the levels of serum creatinine,blood urea nitrogen and serum uric acid of the donor were significantly higher than those before operation(all P＜0.05),but still within the normal range.The patients were followed up for 1,3,5 and 10 years after operation.Compared with 1 month after operation,the serum creatinine,blood urea nitrogen and serum uric acid were relatively stable(all P＞0.05).The eGFR of donors of different ages remained relatively stable for a long time after operation.There were 3 cases of endoscopic hematuria and 4 cases of proteinuria after surgery,and these symptoms were relieved after rest and symptomatic treatment.Ten(11.0%)donors developed hypertension 5(5.5%)developed hyperlipidemia,and 5(5.5%)developed diabetes mellitus.No patient died.Conclusion Nephrectomy is safe and feasible for healthy related donors.To ensure the safety of the donors,comprehensive evaluation before nephrectomy and regular follow-up after nephrectomy are essential.
