Role of mast cells in development of endometriosis pain:research progress
10.16781/j.CN31-2187/R.20230315
- VernacularTitle:肥大细胞参与子宫内膜异位症疼痛机制的研究进展
- Author:
Xinqi MAO
1
;
Xinmei ZHANG
Author Information
1. 浙江大学医学院附属妇产科医院妇科,杭州 310006
- Keywords:
endometriosis;
pain;
mast cells;
inflammation;
angiogenesis;
nerve growth;
neurosensitization
- From:
Academic Journal of Naval Medical University
2024;45(9):1089-1096
- CountryChina
- Language:Chinese
-
Abstract:
Pain is the most common and severe symptom of endometriosis. However,there is no effective treatment nowadays,and the mechanism of endometriosis pain remains poorly defined. Mast cells are immune cells that can interact with sensory nerves to induce endometriosis pain. Recent studies have shown that mast cells play a vital role in the development of endometriosis pain. This article summarizes the latest research to highlight advances in mast cells involving in endometriosis pain through inflammatory response,angiogenesis,nerve growth,and peripheral and central sensitization,hoping to provide new ideas for the mechanism research and clinical treatment of endometriosis pain.
