Inhibitory effect of melatonin on endometriosis:research progress

VernacularTitle:褪黑素对子宫内膜异位症病灶抑制作用的研究进展
Author: Hejun SHOU ¹ ; Hua DUAN
Author Information

1. 首都医科大学附属北京妇产医院/北京妇幼保健院妇科微创中心,北京 100006
Keywords: endometriosis; melatonin; oxidative stress; angiogenesis; estrogen
From: Academic Journal of Naval Medical University 2024;45(9):1083-1088
CountryChina
Language:Chinese
Abstract: Endometriosis (EM) refers to the implantation or growth of endometrial glands and stroma outside the uterus. The pathological mechanism of EM includes immunoinflammatory changes,oxidative stress,epithelial-stromal transition and neovascularization. EM tends to occur in women of reproductive age and seriously affects the reproductive health and quality of life of patients. At present,it is mainly treated through surgery and long-term drug management. Melatonin is an endogenous indoleamine hormone,which has various physiological functions such as antioxidant,anti-inflammatory,immune regulation and apoptosis promotion through different signaling pathways. It has attracted much attention in the treatment of cancer,cardiovascular diseases and nervous system diseases. Recent studies have found that melatonin can also inhibit the development of EM by inhibiting estrogen synthesis and antagonizing angiogenesis,and can effectively relieve pelvic pain. This article reviews the research progress on melatonin in EM in order to provide new ideas for drug therapy of EM.