Nutritional status of pediatric patients undergoing allogeneic hematopoietic stem cell transplantation
10.16151/j.1007-810x.2024.05.001
- VernacularTitle:异基因造血干细胞移植儿童营养状况研究
- Author:
Mei YAN
1
;
Wei-Bing TANG
;
Yong-Jun FANG
;
Jie HUANG
;
Ting ZHU
;
Jin-Yu FU
;
Xiao-Na XIA
;
Chang-Wei LIU
;
Yuan-Yuan WAN
;
Jian PAN
Author Information
1. 南京医科大学附属儿童医院,临床营养科,江苏 南京 210008
- Keywords:
Allogeneic hematopoietic stem cell transplantation;
Growth rate;
Malnutrition;
Chronic graft versus host disease
- From:
Parenteral & Enteral Nutrition
2024;31(5):257-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the changes in the nutritional status of pediatric patients after allogeneic hematopoietic stem cell transplantation(allo-HSCT)for one year,and to analyze the risk factors.Methods:We collected data from 88 pediatric patients who underwent allo-HSCT at the Department of Hematology and Oncology in Children's Hospital of Nanjing Medical University between May 2018 and November 2022.All pediatric patients underwent nutritional status analysis before transplantation,at enrollment,3 months,6 months and 1 year after allo-HSCT.Linear regression model was used to analyze the risk factors for growth rate.Results:The body mass index Z score(BMI-Z)before allo-HSCT was(0.096±1.349),and decreased to(-0.258±1.438)、(-0.715±1.432)、(-0.584±1.444)at enrollment,3 months,6 months after allo-HSCT,and(-0.130±1.317)at 1 year after allo-HSCT(P<0.001).There was no significant change in BMI-Z between pre-transplantation and 1 year after transplantation(P=1.000).Height for age Z score(HAZ)before transplantation was(0.137±1.305)and decreased to(-0.083±1.267)、(-0.221±1.299)、(-0.269±1.282)in 3 months,6 months and 1 year after allo-HSCT(P<0.001).Multivariate linear regression showed that age≥10 years old(P=0.015)and chronic graft-versus-host disease(cGVHD)(P=0.005)were independent risk factors for change in HAZ.Conclusion:The BMI-Z of pediatric patients treated with allo-HSCT returned to the pre-transplantation level after one year,while HAZ continued to decrease.Allo-HSCT may cause impaired growth rate in pediatric patients.Attention should be paid to HAZ changes in pediatric patients before and after allo-HSCT,especially in pediatric patients≥10 years old of age and those with cGVHD.Effective nutritional intervention should be provided in time.
