Research advances in animal model of nonalcoholic fatty liver related hepatocellular carcinoma
10.3969/j.issn.1671-8348.2024.22.025
- VernacularTitle:非酒精性脂肪肝病相关肝细胞癌动物模型的研究进展
- Author:
Linan QU
1
;
Wujian ZHANG
;
Longying GAO
Author Information
1. 哈尔滨医科大学附属第一医院群力院区普外科,哈尔滨 150001
- Keywords:
non-alcoholic fatty liver disease;
hepatocellular carcinoma;
non-alcoholic fatty liver disease-related hepatocellular carcinoma;
animal models
- From:
Chongqing Medicine
2024;53(22):3495-3500
- CountryChina
- Language:Chinese
-
Abstract:
With the improvement of living standards,at least a quarter of the global population has non-alcoholic fatty liver disease(NAFLD),which is considered to be an important cause of the increased incidence of hepatocellular carcinoma(HCC)in recent years.Finding effective means for disease prevention and/or treatment largely relies on deep understanding of the mechanisms of NAFLD to HCC,which needs to con-struct the stable experimental models to simulate the entire process of disease progression in human NAFLD-HCC.This paper summarizes the animal models which are currently used to study NAFLD-HCC and their ad-vantages and disadvantages,in order to provide a basis for the selection of animal models and accelerate the transition from basic study to clinical study.
