Research progress on pyroptosis in sepsis-associated encephalopathy
10.3969/j.issn.1671-8348.2024.22.024
- VernacularTitle:细胞焦亡在脓毒症相关性脑病中的研究进展
- Author:
Yue YIN
1
;
Yushan DUAN
;
Xiaohong WAN
Author Information
1. 昆明医科大学第二附属医院重症医学科,昆明 650000
- Keywords:
pyroptosis;
sepsis-associated encephalopathy;
mitochondria;
reactive oxygen species;
neu-roinflammation
- From:
Chongqing Medicine
2024;53(22):3490-3494,3500
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infec-tion.Sepsis-associated encephalopathy(SAE)is one of the common complications of sepsis patients,which can be seen in 70％of sepsis patients,mainly manifested by sepsis-related cognitive dysfunction,and its pathogen-esis is complex,mainly including mitochondrial dysfunction,oxidative stress,neuroinflammation,autophagy,etc.Pyroptosis is a special type of programmed cell death that is involved in the regulation of inflammation and immune responses.Neuronal pyroptosis plays an important role in the pathogenesis of SAE.This paper re-views the pathologic mechanism,physiological mechanism,related signaling pathways and potential molecular regulatory mechanisms of neurons pyroptosis in SAE in order to provide the new ideas for the prevention and treatment of SAE.
