Analysis on diagnostic efficiency of inflammatory cytokines in chronic obstructive pulmonary disease complicating pneumonia
10.3969/j.issn.1671-8348.2024.22.005
- VernacularTitle:炎症细胞因子在慢性阻塞性肺疾病并发肺炎中的诊断效能分析
- Author:
Wei LI
1
,
2
;
Xu QI
;
Zhongyuan REN
;
Yuguo ZHAO
Author Information
1. 南京医科大学第一附属医院/江苏省人民医院呼吸与危重症医学科,南京 210029
2. 南京市溧水区人民医院/东南大学附属中大医院溧水分院呼吸内科,南京 211200
- Keywords:
chronic obstructive pulmonary disease;
pneumonia;
inflammatory cytokines;
lung function;
correlation
- From:
Chongqing Medicine
2024;53(22):3385-3388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic efficiency of inflammatory cytokines in chronic obstruc-tive pulmonary disease(COPD)complicating pneumonia.Methods A total of 215 patients with COPD admit-ted and treated in the First Affiliated Hospital of Nanjing Medical University from July 2021 to August 2023 were selected as the study subjects.According to whether or not complicating pneumonia,the patients with complicating pneumonia were included in the observation group(n=87)and those with simple COPD were included in the control group(n=128).The changes of inflammation cytokines[procalcitonin(PCT),tumor necrosis factor-α(TNF-α),C reactive protein(CRP),interleukin-6(IL-6),WBC]and lung function indicators[peak expiratory flow rate(PEF),breathing volume in the first second(FEV1),forced vital capacity(FVC)]were compared between the two groups.The diagnostic efficiency of inflammatory cell factors in COPD com-plicating pneumonia as well as the correlation between the inflammatory cytokines and the lung function in the patients with COPD complicating pneumonia were analyzed.Results The levels of PCT,CRP,IL-6,TNF-αand white blood cell count(WBC)in the observation group were significantly higher than those in the control group(P＜0.05),and FEV1,FVC and PEF in the observation group were significantly lower than those in the control group(P＜0.05).The diagnostic efficiency of joint detection of PCT,CRP,IL-6,TNF-α and WBC in diagnosing COPD complicating pneumonia was better,the sensitivity was 90.80％,the specificity was 90.62％,the area under the curve(AUC)was 0.967.The correlation analysis revealed that the PCT,CRP,IL-6,TNF-α and WBC levels in the patients with COPD complicating pneumonia were negatively correlated with FEV1,FVC and PEF levels(P＜0.05).Conclusion The patients with COPD complicating pneumonia exhibit the typical inflammatory responses and deterioration of lung function.The combined detection of relevant in-flammatory indicators has the good diagnostic efficiency for it.
