Mendelian randomization study on causal relationship between gastroesophageal reflux disease and bronchial asthma
10.3969/j.issn.1671-8348.2024.22.001
- VernacularTitle:胃食管反流病与支气管哮喘因果关系的孟德尔随机化研究
- Author:
Lianlian LIU
1
;
Chengxiang WANG
Author Information
1. 北京中医药大学第三附属医院呼吸科,北京 100029
- Keywords:
gastroesophageal reflux;
asthma;
obesity-related asthma;
childhood asthma;
allergic asth-ma;
eosinophilic asthma;
eosinophilic asthma;
Mendelian randomisation analysis
- From:
Chongqing Medicine
2024;53(22):3361-3366
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between gastroesophageal reflux disease(GERD)and different phenotypes of asthma based on Mendelian randomization(MR).Methods The dataset was pooled by genome-wide association studies(GWAS),in which the GERD data contained 602 604 cases,the unspecified asthma data contained 156 078 cases,139 591 cases of obesity-associated asthma,138 474 cases of pediatric asthma,140 308 cases of allergic asthma and 136 633 cases of eosinophilic asthma.The inverse va-riance weighting method was used as the main method of MR analysis,and the weighted median method,sim-ple model,weighted models and MR-Egger conducted the supplement,and the sensitivity analysis was carried out to assess the stability of the results.Results The MR analysis showed that unspecified asthma(OR=1.61,95％CI:1.45-1.77,P＜0.01),obesity-related asthma(OR=2.40,95％CI:1.98-2.90,P＜0.01),Childhood asthma(OR=1.56,95％CI:1.25-1.94,P＜0.01)and allergic asthma(OR=1.47,95％CI:1.25-1.74,P＜0.01)present the forward cause effect,but eosinophilic asthma had no causal relation with GERD(OR=1.31,95％CI:0.95-1.81,P=0.10).The sensitivity analysis showed that the horizontal pleiot-ropy and heterogeneity in the results did not exist.Conclusion GERD could lead to an increased risk of un-specified asthma asthma,obesity-associated asthma,pediatric asthma and allergic asthma,while the effect on eosinophilic asthma is not significant.
