Regulatory role of m6A methylation modification in osteoarthritis

VernacularTitle:m6A甲基化修饰在骨关节炎中的调控作用
Author: Junhao LIU ^{1
,

2} ; Wei WANG ; Song CHEN ; Qingyun XIE
Author Information

1. 中国人民解放军西部战区总医院,成都 610083
2. 西南交通大学医学院,成都 610031
Keywords: m6A methylation modification; methyltransferase-like 3; osteoarthritis; review
From: Chongqing Medicine 2024;53(21):3329-3334,3339
CountryChina
Language:Chinese
Abstract: N6-methyladenosine(m6A)is produced by methylation of the 6th nitrogen atom of ade-nine.The m6A methylation modification is the most common internal modification of RNA,and the modifica-tion process mainly relies on m6A-related enzymes,including methyltransferases,demethylases and binding proteins.The core structure of the methyltransferase complex(MTC)is methyltransferase-like 3(METTL3).The pathogenesis of osteoarthritis(OA)is intricate and complex,and various factors interact with each other.This paper summarizes the mechanism of action of m6A and related enzymes,and elaborates the pathogenesis of os-teoarthritis from the aspects of chondrocytes,proteases,cytokines and signaling pathways,emphatically intro-duces the regulatory role of METTL3 on OA in m6A methylated modification.The aim is to provide new per-spectives on the pathogenesis of osteoarthritis in order to provide new ideas and approaches for the treatment of osteoarthritis.