Prognostic value of CHR after percutaneous coronary intervention in patients with stable coronary artery disease
10.3969/j.issn.1671-8348.2024.21.013
- VernacularTitle:CHR对稳定型冠心病患者PCI术后的预后价值研究
- Author:
Shengbiao ZHAO
1
;
Wei WANG
;
Yang LIU
;
Junjun LIU
Author Information
1. 南京梅山医院心内科,南京 210039
- Keywords:
stable coronary artery disease;
percutaneous coronary intervention;
C reactive protein to high-density lipoprotein-cholesterol ratio;
prognosis
- From:
Chongqing Medicine
2024;53(21):3268-3273
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of C reactive protein(CRP)to high-density lipo-protein-cholesterol(HDL-C)ratio(CHR)in predicting the all-cause mortality after percutaneous coronary in-tervention(PCI)in the patients with stable coronary artery disease(SCAD).Methods A total of 189 patients with SCAD undergoing PCI admitted and treated in this hospital were selected as the study subjects.The pa-tients'data were collected,including the history of hypertension,diabetes,hyperlipidemia,smoking,drug use,etc.,and the relevant indicators such as electrocardiogram,echocardiography,liver function,renal function,blood lipids,blood glucose,Hb,CRP,post-discharge drug treatment regimen and out-of-hospital follow-up re-sults were recorded.The CHR level of the patients was calculated,and the receiver operating characteristic(ROC)curve of CHR was plotted,the grouping was performed according to the cutoff value and the clinical data were compared between the two groups.The Kaplan-Meier survival curve and multivariate Cox risk mod-el were used to analyze the relationship between CHR and all-cause mortality events.Results The follow-up time was 730 d,and 16 cases of all-cause death occurred during the follow-up period.The area under the curve(AUC)of CHR for predicting the all-cause mortality was 0.833(95％CI:0.735-0.930,P＜0.001),and the cut-off value was 2.446.The grouping was performed according to CHR=2.446,there were 52 cases in the high CHR group(CHR≥2.446)and 137 cases in the low CHR group(CHR＜2.446).The diastolic blood pressure level,CRP level and proportion of all-cause mortality in the high CHR group were higher than those in the low CHR group,and the proportion of diabetes mellitus,Hb level,TC level and HDL-C level were lower than those in the low CHR group,and the differences were statistically significant(P＜0.05).The results of Kaplan-Meier survival analysis showed that the incidence rate of all-cause mortality in the high CHR group was higher than that in the low CHR group(Log-Rank x2=26.127,P＜0.001).The multivariate Cox regres-sion analysis results showed that CHR was the independent influencing factor of the occurrence of all-cause mortality after adjusting age,gender,diastolic blood pressure,diabetes mellitus,left ventricular ejection frac-tion,Hb and TC(P＜0.05).Conclusion CHR is an independent predictive factor of all-cause mortality after PCI in the patients with SCAD,and clinic needs to pay attention to.
