Study on relationship between severe COVID-19 and delayed onset myasthenia gravis based on Mendelian randomization
10.3969/j.issn.1671-8348.2024.21.006
- VernacularTitle:基于孟德尔随机化的COVID-19重症与迟发性重症肌无力的关系研究
- Author:
Xiaofeng ZHANG
1
;
Minglu CHE
;
Li YANG
;
Chunqing ZHANG
Author Information
1. 陆军军医大学第二附属医院神经外科,重庆 400037
- Keywords:
coronavirus disease-2019;
late-onset myasthenia gravis;
Mendelian randomization;
genome-wide association study;
sensitivity analyses
- From:
Chongqing Medicine
2024;53(21):3228-3232,3239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential causal relationships between coronavirus disease-2019(COVID-19)susceptibility,hospitalization and severe case with late-onset myasthenia gravis(LOMG)based on Mendelian randomization(MR).Methods The public data from non-overlapping genome-wide association studies were screened,COVID-19 susceptibility,hospitalization and severe case served as the exposure data,and LOMG as the outcome data.The inverse-variance weighted(IVW)method was mainly adopted to evalu-ate the causal effect,which was supplemented by the methods such as MR-Egger method,weighted median method,weighted model and simple model.The sensitivity analysis was performed.Results The genetically predicted severe case of COVID-19 had the positively causal relationship with LOMG(OR=1.01,95％CI:1.00-1.03,P=0.046).The sensitivity analysis results revealed the study results were steady(P＞0.05).No heterogeneity or horizontal pleiotropy was found.Conclusion Severe case of COVID-19 may be associated with an increased risk of LOMG.
