White Matter Injury of Prematurity: Its Mechanisms and Clinical Features.
- Author:
Young Ah LEE
1
Author Information
- Publication Type:Review
- Keywords: Prematurity; Injury; White matter; Periventricular leukomalacia
- MeSH: Brain; Brain Injuries; Central Nervous System; Humans; Infant, Newborn; Ischemia; Leukomalacia, Periventricular; White Matter*
- From:Journal of Pathology and Translational Medicine 2017;51(5):449-455
- CountryRepublic of Korea
- Language:English
- Abstract: A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and further elucidation. The current review will describe the pathophysiological aspects and clinical significance of white matter injury of prematurity, a main form of perinatal brain injury in premature newborns, with a particular emphasis on its potential antenatal components.
