Meta-analysis on correlation between CCR5 rs1799987 and MnSOD rs4880 gene polymorphisms with risk of diabetic nephropathy
10.3969/j.issn.1671-8348.2024.20.017
- VernacularTitle:CCR5 rs1799987、MnSOD rs4880基因多态性与糖尿病肾病风险相关性的meta分析
- Author:
Shisi LIU
1
,
2
;
Bin ZHANG
;
Qiang SUN
Author Information
1. 济宁医学院附属医院重症医学科,山东济宁 272029
2. 济宁医学院临床医学院,山东济宁 272029
- Keywords:
CCR5 rs1799987;
MnSOD rs4880;
diabetic nephropathy;
meta-analysis
- From:
Chongqing Medicine
2024;53(20):3138-3144,3149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between C-C chemokine receptor type 5(CCR5)rs1799987 and manganese superoxide dismutase(MnSOD)rs4880 gene polymorphisms with diabetic nephrop-athy(DN).Methods The retrieved databases included PubMed and Embase.The retrival time wasfrom the database establishemnt to 12 August 2023.The studies on the CCR5 rs1799987 and MnSOD rs4880 polymor-phisms and DN published abroad were retrived.The Newcastle-Ottawa Scale(NOS)was employed for con-ducting the quality assessment.The statistical analysis was performed by using Stata 16.0 software,and the relationship between the CCR5 rs1799987 and MnSOD rs4880 gene polymorphisms with DN occurrence was e-valuated by using OR and 95％CI as the effect sizes.The funnel plots and Egger's test were utilized to assess the publication bias.Results A total of 14 articles were included for conducting the meta-analysis,including 4 470 cases in the DN case group and 4 211 cases in the non-DN control group.The CCR5 rs1799987 and Mn-SOD rs4880 gene polymorphisms had the correlaation with DN(P＜0.05).The Asians,CCR5 rs1799987 and MnSOD rs4880 gene polymorphisms of type 2 diabetes mellitus had the correlation with DN(P＜0.05).The mutant genotypes A and AA in the CCR5 rs1799987 gene,as well as the VV genotype in the MnSOD rs4880 gene could be the risk factors for DN occurrence.Conclusion CCR5 rs1799987 and MnSOD rs4880 gene poly-morphisms have the correlation with DN,especially Asian and patients with type 2 diabetes mellitus.
