Study on causal relationship between walking pace with interverbral disc degeneration and low back pain based on two-sample bidirectional Mendelian randomisation
10.3969/j.issn.1671-8348.2024.20.013
- VernacularTitle:基于双样本双向孟德尔随机化的步行速度与椎间盘退变、腰痛的因果关系研究
- Author:
Chao SU
1
,
2
;
Yuxiao TIAN
;
Lifeng ZHUANG
;
Di XIA
;
Manhong YANG
;
Tianhao WAN
;
Qing ZHANG
Author Information
1. 中国中医科学院望京医院脊柱二科,北京 100102
2. 北京中医药大学临床医学院(望京医院),北京 100105
- Keywords:
walking pace;
intervertebral disc degeneration;
low back pain;
Mendelian randomisation;
causality
- From:
Chongqing Medicine
2024;53(20):3113-3119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between walking pace(WP)with interver-tebral disc degeneration(IVDD)and low back pain(LBP)by using two-sample Mendelian randomisation(MR)analysis method.Methods A genome-wide association study database of WP,IVDD and LBP was ob-tained,and single nucleotide polymorphisms(SNP)strongly associated with exposure were obtained as the in-strumental variables.The two confounders of smoking and sedentary were conservatively removed,and the MR analyses were performed by inverse variance weighting(IVW),weighted median,and MR-Egger methods to assess the causal relationship between WP with IVDD and LBP.The consistency and accuracy of results were ensured by heterogeneity,diversity tests,MR-PRESSO and negative control.Results The I VW results showed a significant negative correlation between WP and IVDD(OR=0.348,95％CI:0.183-0.661,P=0.001)and vice versa(OR=0.972,95％CI:0.953-0.992,P=0.007).Meanwhile there was also a significant negative correlation between WP and LBP(OR=0.214,95％CI:0.119-0.385,P＜0.001),but no causal re-lationship was found between LBP and WP.Conclusion Faster WP could effectively prevent the occurrence of IVDD and LBP,and IVDD may contribute to the occurrence of slow walking.
