Comparison of efficacies among different doses of vitamin D supplementation in preterm infants with vitamin D deficiency and insufficiency
10.3969/j.issn.1671-8348.2024.19.023
- VernacularTitle:补充不同剂量维生素D对早产儿维生素D缺乏和不足的疗效比较
- Author:
Min WANG
1
;
Fei HE
;
Qin CHANG
;
Kuilin LYU
;
Yuping ZHANG
Author Information
1. 中国人民解放军陆军军医大学第二附属医院儿科,重庆 400037
- Keywords:
preterm infants;
vitamin D;
vitamin D deficiency;
vitamin D insufficiency;
supplementation dose of vitamin D;
efficacy
- From:
Chongqing Medicine
2024;53(19):3008-3012
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of different doses of vitamin D supplementation on vita-min D deficiency and insufficiency in premature infants.Methods A total of 126 premature infants hospital-ized in the pediatrics department of this hospital from March 25,2021 to December 30,2022 were selected as the study subjects and began to supplement different doses of vitamin D on 3 d after birth under the intestinal tract tolerance.They were divided into 500,900 and 2 100 IU/d groups according to vitamin D supplementary dose.The differences in vitamin D levels at beginning and after supplementation were compared among the groups.Results Among 126 premature infants,there were 52 cases of vitamin D deficiency and 74 cases of vi-tamin D insufficiency.Compared with vitamin D insufficiency,the proportion of vitamin D supplementation in the mothers of the premature infants with vitamin D deficiency was lower(P＜0.05).The serum calcium,phosphorus,alkaline phosphatase and 25-hydroxyvitamin D levels after birth had no statistical difference a-mong 3 groups(P＞0.05).The 25-hydroxyvitamin D level after supplementation had statistical difference a-mong 3 groups(P＜0.05),moreover the 500 IU/d group was lower than the 2 100 IU/d group(P＜0.05).The longest duration of vitamin D supplementation in the 2 100 IU/d group was 90 d,its highest 25-hydroxyvitamin D level after supplementation was 48.3 ng/mL,no vitamin D poisoning condition appeared,there were still 40 cases(85.1％)of vitamin D deficiency and insufficiency after supplementation in the 900 IU/d group,and 17 cases(25.8％)in the 2 100 IU/d group.Conclusion Giving vitamin D 2 100 IU/d in pre-term infants is recommended after birth to prevent the vitamin D deficiency.
