Relationship between PHOX2B protein and MCYN gene with clinicopathological features and prognosis of peripheral neuroblastic tumors
10.3969/j.issn.1671-8348.2024.19.021
- VernacularTitle:PHOX2B蛋白、MYCN基因与外周神经母细胞性肿瘤临床病理特征及预后的关系
- Author:
Jingyu LI
1
;
Jizhao GAO
Author Information
1. 徐州医科大学附属徐州儿童医院病理科,江苏徐州 221000
- Keywords:
peripheral neuroblastic tumors;
paired like homeobox 2B protein;
N-MYC oncogene;
prog-nosis
- From:
Chongqing Medicine
2024;53(19):2997-3001
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the paired like homeobox 2B(PHOX2B)protein and N-MYC oncogene(MYCN gene)status with the clinicopathological features and prognosis of pe-ripheral neuroblastic tumors(pNT).Methods The PHOX2B protein expression in pNT tissues of 41 children cases of pNT was detected by immunohistochemical staining,the MYCN gene expression status was detected by fluorescence in situ hybridization technique,and their relationship with clinicopathological features and prognosis was analyzed by continuous correction chi-square test and Kaplan-Meier method.Results The im-munohistochemical staining showed that PHOX2B protein was mainly localized in the cell nucleus,and the positive expression rate in pNT tissue was 82.9％.Its expression level was related to the onset age,differenti-ation degree and prognosis of pNT(P＜0.05),and the intensity of PHOX2B protein expression was not relat-ed to the MYCN gene status(P＞0.05).The survival stage in the children patients with MYCN gene amplification was shorter than that in the children patients with no MYCN gene amplification(P＜0.05).Conclusion PHOX2B protein has the diagnostic significance for pNT and could be used as a reliable diagnostic marker for pNT;MY-CN gene status is related to the survival period in the children patients,which can help to judge the prognosis of pNT children patients.
