Expression of p-ERK5 and WT-1 protein in high-grade ovarian serous carcinoma and their relationships with prognosis of patients
10.3969/j.issn.1671-8348.2024.19.018
- VernacularTitle:卵巢高级别浆液性癌中p-ERK5、WT-1蛋白的表达与患者预后的关系
- Author:
Yanmin WANG
1
,
2
;
Yanjuan GUO
;
Conghui LIU
;
Yan CHEN
Author Information
1. 华北理工大学附属医院妇产科,河北唐山 063000
2. 滦州市人民医院妇产科,河北滦州 063799
- Keywords:
high-grade serous ovarian cancer;
p-ERK5;
WT-1;
immunohistochemistry;
prognosis
- From:
Chongqing Medicine
2024;53(19):2981-2986
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of p-ERK5 and WT-1 in cancer tissues of the patients with high-grade serous ovarian cancer(HSOC),and to analyze their relationship with the prognosis of the pa-tients to provide a basis for judging the prognosis of HSOC patients.Methods Fifty-four patients with HSOC visiting in the gynecology and obstetrics department of the Affiliated Hospital of North China University of Technology from January 2008 to December 2019 were selected as the study subjects.The age,clinical stage,lymph node metastasis,complicating ascites,recurrence within 3 years,platinum sensitive,interval debulking surgery(IDS)and CA125 level at first visit were collected.The ovarian cancer tissue samples were collected.The expression levels of p-ERK5 and WT-1 protein in ovarian cancer tissues were detected by immunohisto-chemistry.The expression situation of the two kinds of factors were compared among different clinicopatho-logical features.The Kaplan-Meier method and COX regression analysis were used to evaluate the prognosis of the patients with HSOC.Results The median progress free survival(PFS)in the p-ERK5 and WT-1 protein low-expression groups was 36.0 months and 37.0 months respectively,which in the high-expression groups was 17.0 months and 15.0 months respectively.The median overall survival(OS)in the p-ERK5 and WT-1 protein low expression group was 90.0 months,which in the high expression group was 40.0 months,and the difference was statistically significant(P＜0.001).Conclusion The high expression of p-ERK5 and WT-1 protein is associated with PFS time and OS time.
