Correlation between blood microRNA-133b and soluble FMS-like tyrosine kinase 1 levels and prognosis in patients with endometrial cancer
10.3969/j.issn.1671-8348.2024.19.011
- VernacularTitle:子宫内膜癌患者血微小RNA-133b、可溶性fms样酪氨酸激酶1水平与预后的相关性研究
- Author:
Huihui SUN
1
;
Yanjuan GUO
;
Nannan ZHAO
;
Jianli ZHOU
;
Jinling YUAN
;
Jie GAO
Author Information
1. 华北理工大学附属医院妇科,河北唐山 063000
- Keywords:
endometrial cancer;
prognosis;
microRNA-133b;
soluble FMS-like tyrosine kinase 1
- From:
Chongqing Medicine
2024;53(19):2943-2948
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between blood microRNA-133b(miR-133b)and solu-ble fms-like tyrosine kinase 1(sFLT1)levels with the prognosis in the patients with endometrial cancer.Methods A total of 122 patients with endometrial cancer visited in the gynecology department of this hospital from January 2015 to January 2016 were prospectively selected as the study subjects,and divided into the sur-vival group(n=58)and death group(n=64)according to the 5-year prognosis of the patients with endome-trial cancer.The miR-133b and sFLT1 levels were compared between the two groups.The COX regression was used to analyze the relationship between miR-133b and sFLT1 with the prognosis of the patients with en-dometrial cancer.Results The levels of miR-133b and sFLT1 in the survival group were higher than those in the death group,and the differences were statistically significant(P＜0.05).The median survival time in the miR-133b low-level group was shorter than that in the miR-133b high level group,and the difference was sta-tistically significant(P＜0.05).The median survival time of the sFLT1 low level group was shoeter than that in the sFLT1 high level group,and the difference was statistically significant(P＜0.05).The FIGO stageⅢ-Ⅳ and lymph node metastasis were the independent risk factors for the prognosis of endometrial cancer(P＜0.05),and the pathological G1-G2,high level of miR-133b and sFLT1 were the independent protective factors for the prognosis of endometrial cancer(P＜0.05).Conclusion The miR-133b and sFLTl low levels in the patients with endometrial cancer are associated with the disease progression,and both are the independ-ent risk factors of prognosis.
