Clinical characteristics of patients with HIV/AIDS complicating liver failure and prognostic influencing factors analysis
10.3969/j.issn.1671-8348.2024.19.006
- VernacularTitle:HIV/AIDS合并肝衰竭患者的临床特征及预后影响因素分析
- Author:
Chong TIAN
1
;
Shiping LIAO
Author Information
1. 重庆市公共卫生医疗救治中心消化内科,重庆 400036
- Keywords:
liver failure;
HIV/AIDS;
clinical features;
HAART;
prognosis
- From:
Chongqing Medicine
2024;53(19):2911-2915
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics of the patients with human immunodefi-ciency virus(HIV)/acquired immune deficiency syndrome(AIDS)complicating liver failure,and to analyze the prognosis influencing factors.Methods The clinical data in 47 cases of HIV/AIDS complicating liver fail-ure admitted and treated in Chongqing Municipal Public Health Medical Center and Chongqing Municipal Fifth People's Hospital from January 2017 to August 2020 were retrospectively analyzed.The general data and laboratory indicators of the patients were collected.The multivariate logistic regression was used to ana-lyze the factors affecting prognosis.Results Forty-seven patients with HIV/AIDS complicating liver failure were divided into the cure/improvement group(n=17)and invalid/death group(n=30)according to the prognosis.The proportion of highly active antiretroviral therapy(HAART)in the cure/improvement group was significantly higher than that in the invalid/death group,while the levels of WBC,TBil,DBil,PT and INR,and the incidence rate of hepatic encephalopathy were significantly lower than those in the invalid/death group,and the differences were statistically significant(P＜0.05).The multivariate logistic regression analy-sis showed that HAART and WBC were the independent influencing factors of the prognosis in the patients with HIV/AIDS complicating liver failure(P＜0.05).Conclusion The rational antiviral treatment and effec-tive prevention and treatment of infection could reduce the mortality rate of the patients with HIV/AIDS com-plicating liver failure.
