Meta analysis of OCTA for detecting blood vessel density changes after open-angle glaucoma surgery
10.3969/j.issn.1671-8348.2024.18.022
- VernacularTitle:OCTA检测开角型青光眼术后血管密度改变的meta分析
- Author:
Yu ZHAO
1
;
Rong BAI
;
Hongyan HAO
;
Weibo CHEN
;
Sheng LI
;
Xiao CAO
;
Chen TIAN
;
Jun LI
Author Information
1. 兰州市第一人民医院眼五科,兰州 730000
- Keywords:
optical coherence tomography angiography;
open angle glaucoma;
blood vessel density change;
systematic review;
meta-analysis
- From:
Chongqing Medicine
2024;53(18):2838-2846
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the value of optical coherence tomography angiogra-phy (OCTA) for detecting the vessel density (VD) changes after open-angle glaucoma (OAG) surgery.Meth-ods The studies on OCTA for detecting the VD changes after OAG surgery were searched in the CNKI,WanFang,VIP,SinoMed,PubMed,Embase and Web of Science databases from the database establishment to May 2024.Literature screening,data extraction and risk of bias assessment of included studies were conducted independently by two reviewers.Descriptive analysis was adopoted for the systematic evaluation,the meta a-nalysis was conducted by using the R software and mean difference (MD) and its 95％CI were calculated.Re-sults A total of 13 studies were included,involving 472 patients with 500 tested eyes.The results of meta-a-nalysis showed that compared with pre-surgery,VD around the optic nerve head (ONH) and in nasal superi-or,temporal inferior,temporal superior,superior temporal and superior nasal regions at postoperative 6 months were significantly decreased.VD in the perimacular,perimacular superior hemisphere,permacular su-perior hemisphere,perimacular superior and permacular superior regions at postoperative 6 months were sig-nificantly increased.Conclusion OCTA could effectively detect the postoperative VD changes in the patients with OAG and predict postoperative visual function changes in glaucoma,and could serve as an effective test means for assessing the clinical treatment effect of the patients with OAG.
