Effect of cimetidine aerosol inhalation on preventing and treating oral mucositis in patients receiving hematopoietic stem cell transplantation
10.3760/cma.j.issn.1674-2907.2011.27.017
- VernacularTitle:雾化吸入西咪替丁防治造血干细胞移植患者口腔黏膜炎的效果
- Author:
Bo-Jun JIA
1
;
Hong-Xin WANG
;
Xiao-Jing DONG
;
Yu-Jia XU
;
Yue LI
;
Yong-Jiao JI
Author Information
1. 解放军总医院
- Keywords:
Hematopoietic stem cell transplantation;
Cimetidine;
Oral mucositis;
Aerosol inhalation
- From:
Chinese Journal of Modern Nursing
2011;17(27):3275-3277
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of cimetidine aerosol inhalation on preventing and treating oral mucositis (OM) in patients receiving hematopoietic stem cell transplantation (HSCT). Methods 120 patients receiving HSCT were divided into three groups. The patients in group A ( n =40 ) did not receive aerosol inhalation, the patients in group B (n =40) were treated by normal sodium aerosol inhalation, and the patients in group C ( n =40) were treated by cimetidine aerosol inhalation. The preventive and curative effects between the three groups were observed and compared. Results The incidence rate of OM in group C was 40.0％, was less than no aerosol inhalation group ( 67. 5％ ) and normal sodium aerosol inhalation group (50.0％), the difference was statistically significant(x2 =6. 216,P ＜0. 05). The Ⅱ - Ⅳ degree of OM in three groups were statistically significant( x2 =6.278, P ＜ 0. 05 ) ; the occurrence of OM and the duration were statistically different ( P ＜ 0. 05 ). The occurrence of OM was delay and the duration was shortened in cimetidine aerosol inhalation ( P ＜ 0. 01 ). Conclusions Cimetidine atomizing inhalation is effective on OM in HSCT recipients, the incidence rate of OM decreased significantly, which could reduce the patients' suffering and increase the achievement ratio of HSCT.
