Research progress on role of mitochondrial calcium uniporter in neurodegenerative diseases
10.3969/j.issn.1671-8348.2024.17.025
- VernacularTitle:线粒体钙单向转运体在神经退行性疾病中的作用研究进展
- Author:
Jie ZHOU
1
,
2
;
Yingli YANG
;
Mengran ZHANG
;
Weixia DUAN
Author Information
1. 南京医科大学公共卫生学院,南京 211166
2. 重庆医药高等专科学校附属第一医院实验医学中心/职业病防治与中毒救治重庆市重点实验室,重庆 400060
- Keywords:
mitochondrial calcium uniporter;
neurodegenerative diseases;
imbalance of calcium;
specific inhibitors of mitochondrial calcium uniporter
- From:
Chongqing Medicine
2024;53(17):2691-2697
- CountryChina
- Language:Chinese
-
Abstract:
With the world aging aggravation,the prevalence of neurodegenerative diseases has risen year by year,which brings a huge burden on society and family.However,the effective treatment drugs are still scarce,there is an urgent need to discover new therapeutic targets and develop new therapeutic strategies.Recent studies have found that the the mitochondrial calcium uniporter(MCU)has an important function in many neurodegenerative diseases,the imbalance of mitochondrial calcium homeostasis caused by its abnormal expression or function is one of the important mechanisms of neurodegenerative diseases.Inhibiting the MCU function can play the good neuroprotective role,the specific inhibitors of MCU have shown the good prospect in treating various neurodegenerative diseases.This paper sketched the structure,function,regulatory mecha-nism and specific inhibitors of MCU,and focused on analyzing the role of MCU in the occurrence and develop-ment of different neurodegenerative diseases in order to provide reference for further exploration of MCU as a new therapeutic target for neurodegenerative diseases.
