Research progress on fatty acid metabolism and lipid nephrotoxicity in renal tubular epithelial cells
10.3969/j.issn.1671-8348.2024.17.022
- VernacularTitle:肾小管上皮细胞脂肪酸代谢与脂质肾毒性的研究进展
- Author:
Yinqing CHEN
1
;
Shisheng HAN
;
Yi WANG
Author Information
1. 上海中医药大学,上海 201203
- Keywords:
renal tubules;
epithelial cells;
fatty acid;
lipid nephrotoxicity;
review
- From:
Chongqing Medicine
2024;53(17):2677-2681
- CountryChina
- Language:Chinese
-
Abstract:
The"lipid nephrotoxicity"hypothesis introduces the lipid metabolism disorders into the field of kidney disease research.Fatty acids as important components of lipids can be ectopic deposition in various cells of the kidney in pathological status,and are involved in the occurrence and progression of acute kidney in-jury(AKI)and chronic kidney disease(CKD).The mechanism of abnormal fatty acid metabolism in tubular epithelial cells(TEC)and its function change are closely associated with kidney injury.This article summa-rized the relationship between fatty acid metabolism in TEC with AKI and CKD,elaborated the specific mech-anism of fatty acid metabolism disorders leading to TEC injury,and discussed the treatment strategies based on regulating fatty acid metabolism disorders to improve kidney injury.
