Application and nursing of Tirofiban hydrochloride in PCI of acute myocardial infarction
10.3760/cma.j.issn.1674-2907.2011.26.010
- VernacularTitle:替罗非班在心肌梗死急诊介入治疗中的应用与护理
- Author:
Ai-Hong TANG
1
;
Ding-Feng JIN
Author Information
1. 上海市奉贤区中心医院
- Keywords:
Myocardial infarction;
PCI;
Tirofiban;
Nursing
- From:
Chinese Journal of Modern Nursing
2011;17(26):3128-3131
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy and major nursing characteristics of Tirofiban in emergent PCI treatment of acute myocardial infarction (AMI).Methods The selected 124 patients with undergoing AMI emergency PCI were randomly divided into Tirofiban and control group,and all subjects were treated perioperative anti-thrombotic therapy,Tirofiban groups were treated with additional preoperative application of Tirofiban.Compare the 2 groups with the infarct-related artery PCI,TIMI flow,postoperative degree of ST segment resolution,bleeding complications,major adverse cardiac events (MACE) rate and so on.Take nursing to Tirofiban group during the medicine-taking period and give some instruction to them.Results The postoperative TIMI flow grade of Tirofiban group was significantly higher than the control group (x2 =6.4,P ＜0.05); ST segment resolution defect rate was lower than control group (4.4％ vs 16.1％,x2 =4.78,P ＜0.05); Cardiovascular events was significantly lower (2.9％ vs 16.1％,x2 =5.03,P ＜0.05).Left ventricular ejection fraction was higher than in the conventional group [ ( 57.6 ± 2.3 ) ％ vs (55.3 ± 1.9) ％,t =5.99,P ＜ 0.01 ] ; minor bleeding was higher than the conventional group,the difference was not statistically significant ( P ＞ 0.05 ).Conclusions AMI patients in the routine emergency PCI on the basis of anti-thrombotic therapy in combination with Tirofiban levels can improve myocardial perfusion and left ventricular function,reduce the incidence of MACE after PCI and curative effect,however,it can increase the risk of bleeding resistance,with a effective treatment and close observation,detect and deal with complications in time,to ensure the smooth progress of treatment,improve patient benefits and medication safety.
