Predictive effect of miR-155-5p on chronicity in herpes zoster neuralgia
10.3969/j.issn.1671-8348.2024.16.017
- VernacularTitle:miR-155-5p对带状疱疹性神经痛慢性化的预测作用
- Author:
Qianqian SHEN
1
;
Bo WANG
;
Zhongju DU
;
Jurong XIA
Author Information
1. 杭州市第三人民医院皮肤外科 杭州 310009
- Keywords:
MiR-155-5p;
herpes zoster neuralgia;
chronicity;
forewarning effect
- From:
Chongqing Medicine
2024;53(16):2488-2491
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression and forewarning effect of MiR-155-5p in the chronicity process of herpes zoster neuralgia (HZN).Methods A total of 88 patients with herpes zoster neuralgia (HZN group) and 20 healthy subjects undergoing physical examination (HA group) were selected.The expression level of serum miR-155-5p was measured by reverse transcription real-time fluorescence quantification poly-merase chain reaction (RT-qPCR).The patients with pain after 3-month follow up served as herpes zoster neuralgia (PHN group) and those with pain disappearance served as the cure group (RC group).The expres-sion levels of miR-155-5p were compared between the HZN group and HA group and between the PHN group and RC group.The area under receiver operating characteristic (ROC) curve (AUC) and 95％ confidence in-terval (CI) were calculated for evaluating the efficiency of miR-155-5p in predicting the chronicity of HZN. Results Compared with the HA group,the expression level of miR-155-5p in the HZN group was significant-ly up-regulated,and the difference was statistically significant (P<0.05);compare with the RC group,the ex-pression level of serum miR-155-5p in the PHN group was significantly up-regulated,and the difference was statistically significant (P<0.05);AUC of miR-155-5p for predicting the chronicity of HZN was 0.878 (95％CI:0.808-0.948).Conclusion The expression level of serum miR-155-5p in herpes zoster period of the pa-tients with PHN is significantly up-regulated compared with the cure patients and miR-155-5p could serve as an important predictive indicator of HZN chronicity.
