Effect of sex difference on body weight and body fat in mice
10.3969/j.issn.1671-8348.2024.16.002
- VernacularTitle:性别差异对小鼠体重体脂影响的研究
- Author:
Ziling YAN
1
;
Xue WANG
Author Information
1. 复旦大学发育生物学与分子医学研究所,上海 200438
- Keywords:
gender difference;
obesity;
metabolic effects;
high-fat diet;
body fat content;
glucose metabolism;
insulin sensitivity
- From:
Chongqing Medicine
2024;53(16):2408-2413
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of sex difference on the body weight and body fat in mice.Methods Seventy-seven FVB/NJ background mice models were used and divided into the male mice and female mice.The body weight was measured once a week at 3 to 8 weeks of age.The content of body fat in mice was detected by the small animal nuclear magnetic resonance spectrometer.The glucose metabolism was evaluated by the glucose tolerance test and insulin resistance test.The oxygen consumption,carbon dioxide ex-halation volume and energy consumption of mice were recorded in the energy metabolism experiment.In addi-tion,the differences in body weight,body fat content,glucose metabolism and insulin sensitivity under normal and high fat diet conditions between male mice and female mice were analyzed.Results Starting from 4 weeks of age,the body weight of male mice was significantly higher than that of female mice,while the fat/body weight ratio was lower than that of female mice,and the differences were statistically significant (P<0.05). The glucose tolerance degree[(694.8±129.4)mg·dL-1·h-1 vs. (492.6±130.7)mg·dL-1·h-1]and in-sulin sensitivity[(1008.4±137.0)mg·dL-1·h-1 vs. (798.5±119.9)mg·dL-1·h-1]in the male mice were worse than those in the female mice,and the differences were statistically significant (P<0.05).The ox-ygen consumption volume[(1.60±0.12)mL-1·h-1·g-1 vs. (1.47±0.08)mL-1·h-1·g-1],carbon diox-ide expiration volume[(1.40±0.06)mL-1·h-1·g-1 vs. (1.33±0.08)mL-1·h-1·g-1]and energy con-sumption value[(0.49±0.04)kcal·h-1·g-1 vs. (0.44±0.03)kcal·h-1·g-1]in the male mice were high-er than those in the female mice,and the differences were statistically significant (P<0.05).In the short high lipid diet,the body weight in the male mice was significantly higher than that in the female mice[(23.17±2.67)g vs. (17.96±0.78)g],and the difference was statistically significant (P<0.05).But the body lipid content had statistical difference (P>0.05).Conclusion The sex differences significantly affect the body weight and body fat of mice,meanwhile the male mice are more likely to generate more fat under high fat diet.
