Research progress on tumor necrosis factor receptor 2 in psoriasis
10.3969/j.issn.1671-8348.2024.15.024
- VernacularTitle:肿瘤坏死因子受体2在银屑病中的研究进展
- Author:
Nian MO
1
;
Yating ZHANG
;
Junhong ZHANG
;
Qing WANG
;
Panyu ZHOU
;
Ling HAN
;
Chuanjian LU
Author Information
1. 广州中医药大学第二临床医学院,广州 510006
- Keywords:
psoriasis;
tumour necrosis factor;
tumour necrosis factor receptor 2;
psoriasis treatment;
re-view
- From:
Chongqing Medicine
2024;53(15):2370-2375
- CountryChina
- Language:Chinese
-
Abstract:
Psoriasis is a refractory disease mainly co-acted by immune,genetic and environment.Tumor necrosis factor α (TNF-α)-related biologics have brought the landmark advances in the treatment of psoriasis;however,the anti-TNF-α therapy has the adverse response,its limitation may be related to the different bio-logical functions exerted by activation of TNF-α different receptors.Tumor necrosis factor receptor 2 (TNFR2) is one of the key receptors for TNF-α,and after binding to TNF-α,it can activate multiple signaling pathways such as NF-κB,PI3K/Akt,MAPK,STAT3,etc.,which are involved in the regulation of inflamma-tion,epidermal homeostasis,cellular apoptosis,cellular proliferation,cellular autophagy and other biological processes.It is suggested that TNFR2 is closely related to the occurrence and development of psoriasis.Previ-ous studies have often overlooked the role of TNFR2 in anti-TNF-α therapies;therefore,this article reviews the structure and signaling pathways of TNFR2,research advances in the disease,and its relationship with psoriasis to provide new references for exploring the pathogenesis and treatment of psoriasis.
