Influence of peripheral blood NLR,MLR and PLR in prognosis of patients with multiple myeloma
10.3969/j.issn.1671-8348.2024.15.004
- VernacularTitle:外周血中NLR、MLR及PLR对多发性骨髓瘤患者预后的影响
- Author:
Xinlan XIA
1
,
2
;
Die LIU
;
Lihong AN
;
Yan LI
;
Peng ZHAO
;
Yan ZHANG
;
Mengxing LI
;
Jishi WANG
;
Yinghao LU
Author Information
1. 贵州医科大学,贵阳 550004
2. 贵州医科大学附属医院血液科,贵阳 550004
- Keywords:
multiple myeloma;
complete remission rate;
prognosis;
neutrophil-to-lymphocyte ratio;
platelet-to-lymphocyte ratio;
monocyte-to-lymphocyte ratio
- From:
Chongqing Medicine
2024;53(15):2261-2268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of peripheral blood neutrophil-to-lymphocyte ratio (NLR),monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) on the prognosis in the patients with multiple myeloma (MM).Methods A total of 159 newly diagnosed MM admitted and treated in the Affiliated Hospital of Guizhou Medical University from January 2019 to May 2023 were selected as the study subjects.The general clinical data,blood biochemical and marrow routine detection results before the in-itial treatment were collected.NLR,MLR and PLR were calculated.The univariate and multivariate Cox-re-gression model was adopted to analyze the influencing factors.The receiver operating characteristic (ROC) curve was used to analyze the predictive value.The Kaplan-Meier survival curve and Log-Rank test were used to conduct the survival analysis.Results The ROC curve showed that the critical values of NLR,MLR and PLR were 2.682,0.317 and 147.786 respectively.The patients were divided into the high/low NLR groups (n=61,n=98),high/low MLR group (n=76,n=83) and high/low PLR groups (n=59,n=100).The pro-portions of blood calcium<2.5 mmol/L and creatinine<177 μmmol/L in the low NLR group in the low NLR group were higher compared with the high NLR group (P<0.05);the blood calcium,creatinine and DS stage had statistical differences between the low MLR group and high MLR group (P<0.05);blood calcium had statistical difference between the low PLR group and high PLR group (P<0.05).After 3 treatment courses,the complete remission rate in the high NLR group,high MLR group and high PLR group was significantly lower than that in the corresponding low group (P<0.05).The multivariate Cox-regression analysis results showed that hemoglobin<100 g/L and high PLR were the independent risk factors affecting the progress free survival (PFS) stage in the patients with MM (P<0.05).The age>60 years old was the independent risk factors affecting the overall survival (OS) in the patients with MM (P<0.05).Conclusion NLR,MLR and PLR could serve as the assisted tool to evaluate the prognosis in the patients with MM.
