The Clinical Usefulness of Membranous E-cadherin in Transitional Cell Carcinoma of the Bladder.
- Author:
Bong Ryoul OH
1
;
Gil Joo NAH
;
Seong Jin KIM
;
Jae Hong SIM
;
Dong Deuk KWON
;
Kwang Sung PARK
;
Soo Bang RYU
;
Yang Il PARK
Author Information
1. Department of Urology, Chonnam University Medical School, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
E-cadherin;
Bladder cancer
- MeSH:
Adhesives;
Cadherins*;
Carcinoma, Transitional Cell*;
Cystitis;
Humans;
Prognosis;
Recurrence;
Urinary Bladder Neoplasms;
Urinary Bladder*
- From:Journal of the Korean Cancer Association
1998;30(6):1219-1226
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: E-cadherin, a cell adhesive molecule that plays a diverse role in cell-cell and cell-matrix interaction, is essential for maintaining epithelial intercellular adhesion and acts particularly as a suppressor of invasive ability of cancer. To detennine the potential pro- gnostic values of membranous E-cadherin, we evaluated the correlation between the clin- ical outcome and its expression in patients with transitional cell carcinoma of the bladder. MATERIALS AND METHODS: Membranous E-cadherin immunoreactivity was evaluated in 75 cases of transitional bladder cancer and 15 controls (5 cases of cystitis and 10 normal controls). The expression of membranous E-cadherin were compared with histological grade, T category of TNM stage, and survival. RESULTS: Abnonnal immunohistochemical expression of membranous E-cadherin was observed in 53 (70.7%) patients with bladder cancer and undetected in controis. Abnormal immunohistochemical expression of membranous E-cadherin was significantly correlated with grade (p<0.01) and T category of TNM stage (p<0.01) of transitional cell carcinoma of the bladder. Progression to invasive cancer occurred in 6 patients with 45 superficial bladder cancer and 5 of them showed abnormal expression of E-cadherin, which had statistical significance (p<0.05) but not with recurrence. There was statistically significant correlation between the abnormal expression of E-cadherin and poor prognosis (p < 0.01). CONCLUSIONS: We conclude that abnormal expression of membranous E-cadherin is a useful prognostic marker in patients with transitional bladder cancer.
