Study on predictive effect of abnormal prothrombin,ApoA1 and ApoB on liver cancer occurrence in liver cirrhosis
10.3969/j.issn.1671-8348.2024.14.016
- VernacularTitle:异常凝血酶原、ApoA1和ApoB对肝硬化发生肝癌的预测效果研究
- Author:
Xiangqi LIU
1
;
Tiantian HU
;
Renjie TAN
;
Gang WU
Author Information
1. 西南医科大学附属医院感染科,四川泸州 646000
- Keywords:
abnormal prothrombin;
apolipoprotein A1;
apolipoprotein B;
liver cancer;
influencing factors
- From:
Chongqing Medicine
2024;53(14):2163-2167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influencing factors of liver cancer occurrence in liver cirrhosis,and to construct a risk prediction model.Methods A total of 307 patients with liver cirrhosis admitted and treated in the Affiliated Hospital of Southwest Medical University from August 2019 to December 2022 were selected as the study subjects,among them 175 patients with simple liver cirrhosis were included in the control group and 132 patients with liver cirrhosis complicating liver cancer were included in the observation group.The lev-els of various indicators were detected by the automatic immunofluorescence analyzer and dry biochemical ana-lyzer.The influencing factors of liver cancer occurrence in liver cirrhosis were analyzed by univariate and mult-ivariate logistic regression.The diagnostic efficiency of single detection and combined detection of various in-fluencing factors for liver cancer occurrence in liver cirrhosis was calculated by receiver operating characteristic (ROC) curve.Results The univariate analysis results showed that the age,smoking history,drinking history,family history of liver cancer,AFP,PIVKA-Ⅱ,ApoA1 and ApoB levels had statistical differences between the two groups (P<0.05).The multivariate logistic regression results showed that PIVKA-Ⅱ (OR=1.240,95％CI:1.064-1.445),ApoA1 (OR=26.154,95％CI:1.224-558.648) and ApoB (OR=23.289,95％CI:2.940-184.520) were the independent risk factors for liver cancer occurrence in liver cirrhosis (P<0.05). The ROC curve results showed that the area under the curve of PIVKA-Ⅱ,ApoA1 and ApoB combined detec-tion for predicting the liver cancer occurrence in liver cirrhosis was 0.853 (95％CI:0.756-0.874),and the sensitivity and specificity were 82.33％ and 65.47％,respectively.Conclusion PIVKA-Ⅱ,ApoA1 and ApoB levels are the independent risk factors for liver cancer occurrence in liver cirrhosis,and their combined detec-tion has a good predictive value for liver cancer occurrence in liver cirrhosis.
