Study on relationship between PLCL2 gene polymorphism and large artery atherosclerotic ischemic stroke
10.3969/j.issn.1671-8348.2024.14.013
- VernacularTitle:PLCL2基因多态性与大动脉粥样硬化型缺血性卒中的关系研究
- Author:
Xiaobei WANG
1
,
2
;
Peishan LI
;
Qinfen WU
;
Guofeng ZHU
;
Xinling YANG
Author Information
1. 新疆医科大学第二附属医院神经内科,乌鲁木齐 830063
2. 新疆神经系统疾病临床研究中心,乌鲁木齐 830063
- Keywords:
phosphatidylinositol-specific phospholipase 2;
gene polymorphism;
large artery atherosclerotic ischemic stroke;
genetic model;
relation
- From:
Chongqing Medicine
2024;53(14):2148-2153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between single nucleotide polymorphisms at loci rs4535211,rs75885714,and rs7653834 of phosphatidylinositol-specific phospholipase 2 (PLCL2) gene and large artery atherosclerotic (LAA) ischemic stroke.Methods A total of 105 patients with newly diagnosed LAA ischemic stroke admitted to the Second Affiliated Hospital of Xinjiang Medical University from July 2021 to July 2022 were selected as the observation group,and 103 patients with gender and age matching phys-ical examination in this hospital during the same period were selected as the control group. The clinical data and serum inflammatory markers were collected and compared between the two groups.Genotypes of PLCL2 gene rs4535211,rs75885714 and rs7653834 loci in the two groups were detected,and genotype and allele fre-quencies were calculated.Results The levels of C-reactive protein (CRP),interleukin-6 (IL-6),neutrophil to lymphocyte ratio (NLR),monocyte to high-density lipoprotein-cholesterol ratio (MHR),platelet to lympho-cyte ratio (PLR) and D-dimer in the observation group were higher than those in the control group.The level of high density lipoprotein-cholesterol (HDL-C) was lower than that of the control group (P<0.05). rs7653834 locus was C/C,C/T,T/T genotypes,and the difference between the two groups was statistically significant (P<0.05).The levels of C/C,T/C and T/T genotypes NLR and PLR at rs7653834 locus were sta-tistically significant between the two groups (P<0.05).The analysis results of co-dominant model,dominant model and overdominant model showed that there was statistical significance in rs7653834 locus genotype be-tween the two groups (P<0.05).Conclusion There may be a potential association between rs7653834 locus polymorphism of PLCL2 gene and LAA type ischemic stroke.
