Analysis on risk factors of severe hypocalcemia in ultrasound-guided radiofrequency ablation treatment in patients with secondary hyperparathyroidism
10.3969/j.issn.1671-8348.2024.14.007
- VernacularTitle:超声引导下射频消融治疗继发性甲状旁腺功能亢进患者严重低钙血症危险因素分析
- Author:
Yan GAO
1
;
Jiaxin ZHANG
;
Xiachuan QIN
;
Xisheng XIE
Author Information
1. 川北医学院附属南充市中心医院肾内科,四川南充 637000
- Keywords:
secondary hyperparathyroidism;
radiofrequency ablation;
hypocalcemia;
secondary
- From:
Chongqing Medicine
2024;53(14):2115-2119
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of postoperative severe hypocalcemia (SH) occur-rence in the patients with secondary hyperparathyroidism (SHPT) treated by ultrasound-guided radiofrequen-cy ablation (RFA).Methods A total of 41 patients with SHPT receiving RFA treatment in the Affiliated Nanchong Central Hospital of North Sichuan Medical College from May 2019 to March 2023 were selected as the study subjects.The retrospective analysis was adopted to collect the data such as the basic information,disease information,laboratory and imagiological examination.The patients were divided into the SH group and non-SH group according to whether or not the corrected serum calcium level being lower than 1.8 mmol/L on 1 d after RFA.The univariate and multivariate logistic regression models were used to analyze the related risk factors of SH occurrence after RFA.The receiver operating characteristic (ROC) curve was drawn to test the predictive efficiency of the related risk factors.Results There were 41 patients with SHPT,inclu-ding 19 males and 22 females,with an average age of (49.56±13.64)years old,and 22 cases developed SH on 1 d after RFA.The univariate analysis results showed that preoperative alkaline phosphatase (ALP),C-reac-tive protein (CRP),parathyroid hormone (PTH) and serum calcium levels had statistical differences between the two groups.The multivariate logistic regression analysis results showed that ALP was an independent risk factor for postoperative SH occurrence.The area under the curve (AUC) of adopting ALP for predicting SH occurrence after RFA in the patients with SHPT was 0.895,and the best predicted cut-off value was 323.34 U/L.Conclusion Paying attention to the level of ALP before operation and correcting it reasonably could be conducive to reduce the incidence rate of postoperative SH.
