Effects of dexmedetomidine on oxidative stress brain injury and NOX4 expression after mouse intracerebral hemorrhage
10.3969/j.issn.1671-8348.2024.14.004
- VernacularTitle:右美托咪定对小鼠脑出血后氧化应激脑损伤及NOX4表达的影响
- Author:
Zhengyu YANG
1
;
Qingxiang MAO
Author Information
1. 陆军军医大学大坪医院麻醉科,重庆 400042
- Keywords:
dexmedetomidine;
intracerebral hemorrhage;
oxidative stress;
NOX4
- From:
Chongqing Medicine
2024;53(14):2099-2103,2109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of dexmedetomidine on oxidative stress brain injury and nicotinamide adenine dinucleotide phosphate oxidase (NOX)4 expression after intracerebral hemorrhage in mouse.Methods The mouse intracerebral hemorrhage model was prepared after 30 min intraperitoneal injec-tion of dexmedetomidine. The neurological motor function,brain water content,NOX4 mRNA content,NOX4 protein expression level and oxidative stress levels were detected.Results Compared with the control group,the neurological motor function score in the intracerebral hemorrhage group was significantly increased (P<0.05),the brain water content was increased (P<0.05),the NOX4 mRNA and NOX4 protein expression levels were significantly increased (P<0.05),the oxidative stress level was increased;but the neurological motor function score in the dexmedetomidine group was significantly decreased (P<0.05),the brain water content was significantly decreased,the NOX4 mRNA and NOX4 protein expression levels were significantly decreased (P<0.05) and the oxidative stress level was decreased.Conclusion Dexmedetomidine could inhibit the NOX4 expression after intracerebral hemorrhage and alleviate the oxidative stress brain injury in mice.
