Relationship between PI3K/Akt/mTOR signal pathway and autophagy regulation and related diseases

VernacularTitle:PI3K/Akt/mTOR信号通路与自噬调控及相关疾病关系
Author: Weisheng LI ¹ ; Tingting WANG ; Wenqiang HE
Author Information

1. 河南中医药大学,郑州 450003
Keywords: PI3K/Akt/mTOR signaling pathway; autophagy; disease; review
From: Chongqing Medicine 2024;53(13):2047-2052
CountryChina
Language:Chinese
Abstract: Phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamy-cin(mTOR)signaling pathway is an important regulating pathway for metabolism,proliferation and survival in cells,and plays a pivotal role in maintaining cellular homeostasis.This signaling pathway participates in the occurrence and development process of multiple diseases by mediating the cellular autophagy,such as tumors,neurodegenerative disorders(ND)and metabolic diseases.This paper reviews the role of PI3K/Akt/mTOR signaling pathway in autophagy regulation in order to better understand the regulatory mechanisms of cellular metabolism and survival,moreover investigate the role of this signal pathway in multiple diseases and direc-tion of the future study to provide reference for explore the new disease treatment methods.