Research progress on role of macrophage polarization in inflammatory bowel disease
10.3969/j.issn.1671-8348.2024.12.024
- VernacularTitle:巨噬细胞极化在炎症性肠病中作用的研究进展
- Author:
Xiaorui SUN
1
;
Jinming ZHANG
;
Zhiyun FANG
;
Haiyan SHEN
Author Information
1. 蚌埠医科大学,安徽蚌埠 233000
- Keywords:
macrophages;
polarization;
inflammatory bowel disease;
treatment;
review
- From:
Chongqing Medicine
2024;53(12):1889-1895
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease(IBD)is a group of chronic non-specific intestinal inflammatory diseases with unclear etiology.Its pathogenesis may be related to the intestinal immune imbalance caused by the interaction of multiple factors such as environment,genetics and intestinal microecology.Macrophages,as an important component of the immune system,can maintain a balance between pro-inflammatory and anti-in-flammatory responses in the intestine.Macrophages can be divided into two polarization types:classical activa-tion(Ml)and alternative activation(M2)according to the different phenotypes and cytokines secreted by macrophages.The polarization of macrophages plays a key role in the subside of intestinal inflammation and the healing of mucosa.In the intestinal immune system of IBD,the imbalance between pro-inflammatory and anti-inflammatory factors caused by macrophage polarization imbalance can lead to sustained progression of intestinal mucosal inflammation and impairment of barrier function,playing a key role in IBD.The changes in macrophage polarization levels may affect the therapeutic effect of IBD.Therefore,targeting macrophage po-larization may be an important target for the treatment of IBD.This article summarizes the role of intestinal macrophage polarization in IBD and the impact of regulating macrophage polarization in IBD treatment to pro-vide reference for studying the new treatment methods for IBD.
