Progress and prospect of intra-arterial thrombolytic therapy for acute cerebral infarction

VernacularTitle:急性脑梗死动脉溶栓治疗的进展与展望
Author: Kangmeng WANG ¹ ; Zhenqiang ZHAO ; Bo ZHAO ; Wei LI
Author Information

1. 海南医学院第一附属医院神经内科,海口 570100
Keywords: acute cerebral infarction; intra-arterial thrombolytic; interventional therapy; alteplase; digit-al subtraction angiography; review
From: Chongqing Medicine 2024;53(12):1883-1888
CountryChina
Language:Chinese
Abstract: Acute cerebral infarction(ACI)is now a major cause of disability worldwide,and also the leading pathogenesis of causing death and causing disability among the residents in our country.Successful re-canalization of cerebral vessels is the key to achieve good prognosis.At present,the thrombolytic treatment is the main measure for rescuing the ischemic penumbra and treating the patients with ACl.Although intrave-nous thrombolysis(IAT)is still the preferred treatment for clinicians.However after long-term research and clinical practice,it has been widely recognized that compared with intravenous thrombolysis(IVT),IAT can significantly increase the concentration of intravascular drugs,increase the vascular revascularization rate,ex-pand the thrombolytic time window,morevover which is safe and reliable.With the development and progress of medical equipment and thrombolytic drugs,IAT still has great space for development.This paper reviews the operation mode of IAT,thrombolytic treatment progress and its future prospects.