Effects of transcranial direct current stimulation on whole brain network topologic attributes in mild cognitive impairment
10.3969/j.issn.1671-8348.2024.12.017
- VernacularTitle:经颅直流电刺激对轻度认知障碍全脑网络拓扑属性的影响
- Author:
Yi LI
1
,
2
;
Zhiwei GUO
;
Kelan LIU
;
Zihan TANG
;
Qiwen MU
Author Information
1. 西南医科大学附属医院放射科,四川泸州 646000
2. 川北医学院第二临床医学院脑功能康复与成像研究所,四川南充 637000
- Keywords:
mild cognitive impairment;
graph theoretic analysis;
transcranial direct current stimulation;
magnetic resonance imaging;
brain network
- From:
Chongqing Medicine
2024;53(12):1844-1849,1855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of transcranial direct current stimulation(tDCS)on the topologic attributes of brain functional network in the patients with mild cognitive impairment(MCI).Meth-ods Thirty-three included patients with MCI were randomly divided into the real stimulation group(18 ca-ses)and pseudo-stimulation group(15 cases).All patients received the tDCS treatment for consecutive 10 d.The left dorsolateral prefrontal cortex(DLPFC)was stimulated by the anode,while the right orbital socket DLPFC was stimulated by the cathode.The neuropsychological scale assessment and resting state functional magnetic resonance imaging(rs-fMRI)image collection were performed before and after treatment.The GRETNA software was used to preprocess the rs-fMRI images and analyze the graph theory.The Pearson correlation analysis was used to calculate the correlation between behavioral indicators and network attribute indicators of significant difference between the two groups.Results There were statistically significant differ-ences in the node attributes(intermediate number centrality,degree centrality and local efficiency of nodes)before and after treatment,and between the two groups after treatment(P＜0.05).Compared with before treatment,the scores of MMSE,MoCA,AVLT-N7 and BNT after treatment in the real stimulation group were significantly increased[(25.89±2.16)points,(21.16±2.77)points,(4.95±1.81)points,(19.47±3.13)points].Conclusion tDCS could effectively regulate the local topological attributes of nodes in the cognitive-related brain region of MCI and improve the cognitive function.
