Research progress on effect of nerve growth factor on fracture healing
10.3969/j.issn.1671-8348.2024.11.024
- VernacularTitle:神经生长因子对骨折愈合影响的研究进展
- Author:
Yikun WANG
1
;
Yongping WANG
Author Information
1. 兰州大学第一临床医学院,兰州 730030
- Keywords:
nerve growth factor;
fracture healing;
bone nonunion;
mechanism;
review
- From:
Chongqing Medicine
2024;53(11):1726-1731
- CountryChina
- Language:Chinese
-
Abstract:
Fracture is a pathological change caused by direct violent injury,indirect violent injury or cu-mulative strain,which results in the destruction of bone continuity and loss of integrity.Fracture healing is a complex biological process of bone regeneration,which can be divided into the hematoma inflammatory organi-zation stage,primitive callus formation stage and callus reconstruction and shaping stage.In the process of fracture healing,the granulation tissue grows into the hematoma site to absorb blood clots,nerves and new capillaries grow into the fracture site,large callus is formed,callus is remodeled and normal bone structure is eventually restored.In this process,there are many substances involving in the regulation of fracture healing,in which nerve growth factor (NGF) plays a certain role,NGF can promote the fracture healing through mul-tiple pathways.This article reviews the effects of nerve growth factors on fracture healing.
