Risk factors of complicating pulmonary hypertension in patients with chronic obstructive pulmonary disease:a meta-analysis
10.3969/j.issn.1671-8348.2024.11.022
- VernacularTitle:慢性阻塞性肺病患者并发肺动脉高压的危险因素meta分析
- Author:
Xun ZOU
1
;
Xiaohong TANG
;
Da JING
;
Yang YANG
Author Information
1. 电子科技大学医学院,成都 610056
- Keywords:
chronic obstructive pulmonary disease;
pulmonary arterial hypertension;
risk factors;
meta analysis
- From:
Chongqing Medicine
2024;53(11):1711-1716
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the risk factors for complicating pulmonary hyperten-sion (PH) in the patients with chronic obstructive pulmonary disease (COPD).Methods The databases of PubMed,Embase,Cochrane Library,VIP,CNKI,China Biomedical Literature Service System and Wanfang Database were retrieved by computer.The retrieval time limitation was from the establishment of the database to September 2023.The literatures on the risk factors for complicating PH in the patients with COPD was col-lected and the meta analysis was conducted by using the RevMan 5.3 software.Results A total of 18 articles were included,including 8 prospective studies and 10 retrospective studies,with a total of 4361 COPD pa-tients,including 8 risk factors.The meta analysis results showed that the risk factors with statistical signifi-cance included C-reactive protein (CRP)[OR(95％CI)=2.17 (1.49-3.14)],interleukin-6 (IL-6)[OR(95％CI)=2.07 (1.59-2.70)],tumor necrosis factor-α (TNF-α)[OR(95％CI)=1.69 (1.28-2.22)],brain na-triuretic peptide (BNP)[OR(95％CI)=1.58 (1.35-1.85)],D-dimer (D-D)[OR(95％CI)=2.58 (1.99-3.35)],forced expiratory volume in one second (FEV1)[OR(95％CI)=2.49 (1.93-3.20)]and mean plate-let volume (MPV)[OR(95％CI)=1.69 (1.19-2.39)].Conclusion CRP,IL-6,TNF-α,BNP,D-D,FEV1 and MPV are the risk factors for complicating PH in COPD patients.
