Study on effect of optimized nutrition intervention during transplantation in allo-HSCT patients
10.3969/j.issn.1671-8348.2024.11.016
- VernacularTitle:allo-HSCT患者移植期间优化营养干预的效果研究
- Author:
Shanshan DU
1
;
Qian BAI
;
Wenyi ZHU
;
Xinyu LIANG
;
Jun TAO
;
Jing WEN
;
Jian WANG
Author Information
1. 陆军军医大学第二附属医院 营养科,重庆 400037
- Keywords:
allogeneic hematopoietic stem cell transplantation;
nutrition intervention;
nutritional status;
weight;
gastrointestinal symptoms
- From:
Chongqing Medicine
2024;53(11):1679-1683,1689
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of optimized nutrition intervention scheme on nutritional status and clinical outcome during transplantation in the patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods Seventy inpatients with allo-HSCT in this hospital from January to December 2022 were selected as the study subjects and divided into the control group and intervention group by the random number table method,35 cases in each group.The control group conducted the conventional nutritional intervention and the intervention group conducted the optimized nutritional intervention.The nutri-tional indicators[body weight,patient-generated subjective global assessment (PG-SGA),energy and protein intake],levels of total protein (TP),albumin (ALB) and prealbumin (PA),hospitalization duration,hospitali-zation costs and adverse reactions occurrence were compared between the two groups.The differences in the nutritional status and clinical outcomes in the tow groups were comprehensively evaluated.Results Compared with the control group,the body weight decrease ranges in entering the laminar flow ward and on 60 d of transplantation in the intervention group were much less[3.10(1.10,4.80)kg vs. 4.30(3.10,6.70)kg;3.20 (1.00,5.50)kg vs. 4.15(3.33,7.88)kg],the PG-SGA score was lower[(10.43±3.25)points vs. (13.00±3.05) points],the PA level was higher[(189.63±51.29)mg/L vs. (163.83±48.03)mg/L],the energy and protein oral intakes were much more[(753.99±350.66)kcal vs. (539.96±247.65)kcal;(33.87±15.87)g vs. (20.43±12.57)g],the diarrhea occurrence rate was lower (14.3％ vs. 37.1％),and the differences were statistically significant (P<0.05).Conclusion Optimizing the nutritional intervention during allo-HSCT pe-riod is beneficial to improve the nutritional status of the patients,and reduce the incidence rate of adverse reac-tions.
