Expression of FGF19 in neonatal hyperbilirubinemia and its correlation with intestinal flora characteristics and β-glucuronidase activity
10.3969/j.issn.1671-8348.2024.11.013
- VernacularTitle:FGF19在新生儿高胆红素血症的表达及其与肠道菌群特点、β-GD活性的相关性
- Author:
Lijia CHEN
1
;
Huan CHEN
;
Ying WANG
;
Yufeng WEI
;
Liwei YE
;
Jun ZHANG
Author Information
1. 大庆龙南医院儿科,黑龙江大庆 163000
- Keywords:
fibroblast growth factor 19;
newborn;
hyperbilirubinemia;
intestinal flora characteristics;
beta-glucuronidase
- From:
Chongqing Medicine
2024;53(11):1666-1669
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of fibroblast growth factor (FGF)19 in neonatal hyperbilirubinemia and its correlation with intestinal flora characteristics and β-glucuronidase (β-GD) activity. Methods Seventy-five neonates with hyperbilirubinemia in Daqing Longnan Hospital from January 2022 to January 2023 were selected as the observation group and 45 neonates with non-hyperbilirubinemia during the same period were selected as the control group.Serum FGF19,total bilirubin and total bile acid levels,intesti-nal flora characteristics and β-GD activity were compared between the two groups.The correlation between FGF19,intestinal flora and β-GD activity with serum total bilirubin level and total bile acid (TBA) level in newborns with hyperbilirubinemia and the correlation between FGF19 with the intestinal flora characteristics and β-GD activity were analyzed by the Pearson method.Results The serum FGF19 level in the observation group was lower than that in the control group,the total bilirubin and TBA levels and β-GD activity were higher,the number of bifidobacterium and Lactobacillus were much less,the number of Escherichia coli was more,and the differences were statistically significant (P<0.05).The FGF19 level and number of bifidobac-terium and Lactobacillus in newborns with hyperbilirubinemia were negatively correlated with the levels of se-rum total bilirubin and TBA levels,while the number of Escherichia coli and β-GD activity were positively cor-related with the levels of serum total bilirubin and TBA (P<0.05).FGF19 in hyperbilirubinemia neonates was positively correlated with the number of bifidobacterium and Lactobacillus,and negatively correlated with Escherichia coli and β-GD activity (P<0.05).Conclusion The serum FGF19 in neonates with hyperbilirubinemia is abnormally low expressed,moreover which is related to intestinal flora disturbance and β-GD activity.
