Monitoring and safety evaluation of coagulation indexes in 246 patients with DVT catheter directed thrombolysis
10.3969/j.issn.1671-8348.2024.10.005
- VernacularTitle:246例DVT置管溶栓患者凝血指标监测与安全评价
- Author:
Huiling LI
1
;
Liping LIU
;
Jiaxin DENG
Author Information
1. 重庆医科大学附属第一医院血管外科,重庆 400016
- Keywords:
deep venous thrombosis;
catheter directed thrombolysis;
coagulation function;
monitoring frequency;
safety
- From:
Chongqing Medicine
2024;53(10):1467-1471
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the monitoring frequency and safety of coagulation function in patients with deep venous thrombosis(DVT)catheter directed thrombolysis during thrombolysis.Methods From January 2014 to December 2021,a total of 246 patients with DVT catheter directed thrombolysis in the hospital were selected as the research objects.According to the monitoring frequency of coagulation function,they were di-vided into group A(160 patients were monitored every 24 hours)and group B(86 patients were monitored every 12 hours).The medication regimen,clinical efficacy,bleeding complications and the time trend of coagu-lation function monitoring were compared between the two groups.Results There were no significant differ-ences in urokinase dosage[240(160,320)million U vs.210(160,270)million U]and the clinical efficacy(88.12％vs.88.37％)in group A and group B(P＞0.05).The incidence of minor bleeding in group A was lower than that in group B(15.62％vs.27.91％),with statistical significance(P＜0.05).There was no sta-tistical difference between group A and group B in the changes of D-dimer,fibrinogen and activated partial thromboplastin time with time(P＞0.05).Compared with the change of platelet(PLT)with time in group A and group B,the difference was statistically significant(P＜0.05).Conclusion The overall change trend of coagulation function with monitoring frequency every 24 or 12 hours is consistent,and monitoring coagulation function once every 24 hours will not increase the risk of bleeding.
