Research progress of autophagy in fibrotic diseases
10.3969/j.issn.1671-8348.2024.09.023
- VernacularTitle:自噬在纤维化疾病中的研究进展
- Author:
Ping NIE
1
;
Hu LI
;
Hongtao ZHU
;
Jianguo HU
Author Information
1. 重庆医科大学附属第二医院妇产科,重庆 400010
- Keywords:
autophagy;
fibrosis;
intrauterine adhesion;
organ failure;
review
- From:
Chongqing Medicine
2024;53(9):1406-1411
- CountryChina
- Language:Chinese
-
Abstract:
Fibrosis is a common pathological change in clinical end-stage diseases,which can occur in any organ and is also a major burden of global health care.Persistent fibrosis can lead to organ failure and seri-ously threaten the life and health of patients,but its mechanism is still unclear.With the deepening of the re-search on fibrosis in modern science,the application of single cell genomics has brought new insights into the exploration of fibrosis tissue biology and disease mechanism in clinic.Since the discovery of autophagy,more and more studies at home and abroad have confirmed that autophagy is involved in the occurrence and develop-ment of fibrosis,which provides a new direction for the treatment of organ fibrosis.This article summarizes the effects of autophagy on organs such as lung and uterus,and summarizes the research progress of autoph-agy pathway in organ fibrosis in recent years,in order to provide new ideas for the treatment of organ fibrosis.
