Research progress on epigenetic factors for adolescent idiopathic scoliosis progression risk
10.3969/j.issn.1671-8348.2024.09.020
- VernacularTitle:青少年特发性脊柱侧凸进展风险的表观遗传学因素研究进展
- Author:
Xiaomei LIU
1
;
Yanyang WANG
;
Min LIU
;
Qian WANG
Author Information
1. 四川大学华西医院康复医学中心,成都 610041
- Keywords:
adolescent;
idiopathic scoliosis;
epigenetics;
risk of progression;
review
- From:
Chongqing Medicine
2024;53(9):1401-1405,1411
- CountryChina
- Language:Chinese
-
Abstract:
Adolescent idiopathic scoliosis (AIS) is a highly heterogeneous condition,with some patients showing marked progressive exacerbation and others relatively stable.Accurate identification of patients at high risk of progression can help to intervene early in treatment to control scoliosis progression and avoid over medication of patients at low risk of progression.Epigenetic factors dynamically regulate gene expression without altering the gene sequence,fully reflecting genetic and environmental interactions,and hold great po-tential in predicting AIS progression.Recent studies have reported numerous epigenetic factors associated with AIS progression and have shown positive results in the prediction of AIS progression.This article provides an overview of research progress on epigenetic factors at risk for AIS progression,with the expectation that it will provide ideas for subsequent AIS treatment and research.
