Effect of luteinizing hormone change amplitude in follicular phase on infertility patients' ovarian response and pregnancy outcome in gonadotropin-releasing hormone antagonist protocol
10.3969/j.issn.1671-8348.2024.09.016
- VernacularTitle:拮抗剂方案中卵泡期黄体生成素变化幅度对不孕症患者卵巢反应性及妊娠结局的影响
- Author:
Jing AN
1
;
Panpan SHI
;
Xiang ZHANG
;
Youyi CHEN
;
Yang YANG
;
Jing ZHAO
Author Information
1. 西安市人民医院/西安市第四医院生殖医学中心,西安 710004
- Keywords:
fertilization in vitro;
gonadotropin-releasing hormone antagonist;
luteinizing hormone;
ovarian response;
pregnancy outcome
- From:
Chongqing Medicine
2024;53(9):1365-1370
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of luteinizing hormone (LH) change amplitude in follicular phase on ovarian response and pregnancy outcome after fresh embryo transfer cycle in infertility patients with normal ovarian function during controlled ovarian hyperstimulation (COH) with antagonist protocol. Methods A total of 277 infertility patients who underwent in vitro fertilization and embryo transfer (IVF-ET) in the Center for Reproductive Medicine of this hospital from January 2019 to December 2021 were se-lected.Patients were divided into the high LH group (n=91),medium LH group (n=93) and low LH group (n=93) according to the tertiles of changes between LH level on the fourth day of COH and basal LH level before COH administration.The basic clinical features,use of exogenous gonadotropin (Gn) during COH, hormone levels at different periods,indexes of ovarian response,laboratory outcomes and pregnancy outcomes during fresh embryo transfer cycle were compared among all groups.Results There was no significant differ-ence in age,infertility duration,infertility types,basal follicle stimulating hormone (FSH),estradiol and tes-tosterone levels among the three groups (P>0.05).The duration of use of Gn in the high LH group was the shortest,the total amount and initiation dose of Gn was the smallest,and the estradiol level,ovarian sensitivity index (OSI),numbers of oocytes,metaphase Ⅱ(MII) oocytes,diprokaryotic fertilization,embryo formation and high-quality embryos were the highest after exogenous Gn stimulation,and the differences were statisti-cally significant compared with the other two groups (P<0.016).There was no significant difference in the clinical pregnancy rate,biochemical pregnancy rate and early miscarriage rate during fresh embryo transfer cy-cle among the three groups (P>0.05).Conclusion The infertility patients with normal ovarian function who have a large decrease in LH level during COH with antagonist protocol can obtain better embryo quantity and quality,but there was no effect on the pregnancy outcome during fresh embryo transfer cycle.
